Treatment Options for Severe Refractory Gout When Pegloticase Fails 

Pegloticase is a new alternative therapy for patients with severe, refractory gout unresponsive to other urate-lowering agents. The goal of this therapy is to reduce disease burden, tophi size and frequency of flares and to improve quality of life when other treatments have failed. Persistent lowering of plasma uric acid (PUA) to less than 6 mg/dL, while achieving the therapy’s goal, is considered successful treatment.

Herein, we present a case of severe refractory gout in a patient unresponsive to all standard urate-lowering therapies, as well as treatment with pegloticase.

http://www.the-rheumatologist.org/article/treatment-options-severe-refractory-gout-pegloticase-fails/5/